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HOMA-IR stands for Homeostatic Model Assessment of Insulin Resistance. It is a widely used method to estimate how well your body responds to insulin, calculated from two simple fasting blood tests: fasting glucose and fasting insulin.
Developed by Matthews et al. in 1985, HOMA-IR is used in clinical research and medical practice worldwide to assess insulin resistance — a condition where the body's cells become less responsive to insulin, requiring the pancreas to produce more insulin to keep blood sugar levels normal.
Why It Matters:
Insulin resistance is often a silent precursor to Type 2 diabetes, developing years before blood sugar levels become abnormal. Early detection through HOMA-IR allows for timely lifestyle interventions that can reverse or delay progression.
